Effect of subcutaneously administered 2,6,10,14-tetramethylpentadecane on plasmacytoma growth.
نویسندگان
چکیده
2,6,10,14-Tetramethylpentadecane (pristane), s.c. injected simultaneously with plasmacytoma inocula, enhances the transplantability of tumor cells. The effect is dose and time dependent. The enhancement is shown only by plasmacytoma (MOPC-315 and MPC-11) and not by the murine lymphosarcoma and chondrosarcoma tested. Various mechanisms, such as stress and depression of humoral and cellular immunity, have been considered.
منابع مشابه
Transplantation of primary plasma cell tumor without 2,6,10,14- tetramethylpentadecane (pristane) treatment of the hosts.
Small inocula of primary plasma tumor cells which do not transplant i.p. unless recipients are conditioned with pristane do so readily when recipients are given i.p. injections of a peritoneal exudate induced by pristane inoculating, but free of pristane.
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Virtually all murine plasmacytomas carry chromosomal translocations that activate c-myc. The predominant (=90%) c-myc-activating chromosomal translocation in pristane (2,6,10,14-tetramethylpentadecane)-induced plasmacytomas in BALB/c mice is a reciprocal translocation t(12;15) in which an immunoglobulin heavy-chain switch sequence is joined to the 5' region of c-myc. The most common switch regi...
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ورودعنوان ژورنال:
- Cancer research
دوره 40 7 شماره
صفحات -
تاریخ انتشار 1980